Mouse Irf9 activation kit by CRISPRa

CAT#: GA202189

Irf9 CRISPRa kit - CRISPR gene activation of mouse interferon regulatory factor 9

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Irf9
• Locus ID: 16391
• Kit Components:

  GA202189G1, Irf9 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202189G2, Irf9 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202189G3, Irf9 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001159417, NM_001159418, NM_008394
• Synonyms: Irf-9; Isgf3g; p48
• Summary: Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. [UniProtKB/Swiss-Prot Function]