Mouse Itga3 activation kit by CRISPRa

CAT#: GA202194

Itga3 CRISPRa kit - CRISPR gene activation of mouse integrin alpha 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Itga3
• Locus ID: 16400
• Kit Components:

  GA202194G1, Itga3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202194G2, Itga3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202194G3, Itga3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001306071, NM_001306162, NM_013565
• Synonyms: AA407068; CD49C; GAPB3
• Summary: This gene encodes a subunit of integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded protein non-covalently associates with the integrin beta-1 subunit to form a heterodimer that interacts with many extracellular matrix proteins including fibronectin and laminin. Mice lacking the encoded protein die during the first day after birth due to severe abnormalities in kidneys. Mice lacking the encoded protein specifically in the basal layer of epidermis display several skin defects and accelerated wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]