Mouse Itga5 activation kit by CRISPRa

CAT#: GA202196

Itga5 CRISPRa kit - CRISPR gene activation of mouse integrin alpha 5 (fibronectin receptor alpha)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Itga5
• Locus ID: 16402
• Kit Components:

  GA202196G1, Itga5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202196G2, Itga5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202196G3, Itga5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001314041, NM_010577
• Synonyms: Cd49e; Fnra; VLA5
• Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain, which is proteolytically processed to generate light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]