Mouse Itga6 activation kit by CRISPRa

CAT#: GA202197

Itga6 CRISPRa kit - CRISPR gene activation of mouse integrin alpha 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Itga6
• Locus ID: 16403
• Kit Components:

  GA202197G1, Itga6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202197G2, Itga6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202197G3, Itga6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001277970, NM_008397
• Synonyms: 5033401O05Rik; AI115430; Cd49f; VLA-6
• Summary: This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 4 to bind laminin and to form the main component of hemidesmosomes, which mediate attachment of epithelia to basement membranes. In mouse, deficiency of this gene is associated with absence of hemidesmosomes, severe skin blistering, and early post-natal death. In humans mutations of this gene are associated with epidermolysis bullosa. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]