Mouse Kcnj2 activation kit by CRISPRa

CAT#: GA202268

Kcnj2 CRISPRa kit - CRISPR gene activation of mouse potassium inwardly-rectifying channel, subfamily J, member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Kcnj2
• Locus ID: 16518
• Kit Components:

  GA202268G1, Kcnj2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202268G2, Kcnj2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202268G3, Kcnj2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008425
• Synonyms: IRK1; Kcnf1; Kir2.1
• Summary: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. [UniProtKB/Swiss-Prot Function]