Mouse Klkb1 activation kit by CRISPRa

CAT#: GA202338

Klkb1 CRISPRa kit - CRISPR gene activation of mouse kallikrein B, plasma 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Klkb1
• Locus ID: 16621
• Kit Components:

  GA202338G1, Klkb1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202338G2, Klkb1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202338G3, Klkb1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008455
• Synonyms: APS; Kal-3; Kal3; Klk3; PSA
• Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric enzyme comprised of heavy and light chains. A complete deletion of the encoded protein prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding. [provided by RefSeq, May 2016]