Mouse Dsg4 activation kit by CRISPRa

CAT#: GA202400

Dsg4 CRISPRa kit - CRISPR gene activation of mouse desmoglein 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Dsg4
• Locus ID: 16769
• Kit Components:

  GA202400G1, Dsg4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202400G2, Dsg4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202400G3, Dsg4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_181564
• Synonyms: CDHF13; lah
• Summary: This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. This gene is expressed in the suprabasal epidermis and hair follicle. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Certain mutations in this gene are responsible for the lanceolate hair phenotype in mice. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Feb 2016]