Mouse Gzmm activation kit by CRISPRa

CAT#: GA202469

Gzmm CRISPRa kit - CRISPR gene activation of mouse granzyme M (lymphocyte met-ase 1)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gzmm
• Locus ID: 16904
• Kit Components:

  GA202469G1, Gzmm gRNA vector 1 in pCas-Guide-CRISPRa

  GA202469G2, Gzmm gRNA vector 2 in pCas-Guide-CRISPRa

  GA202469G3, Gzmm gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001302485, NM_001302499, NM_008504, NR_126325
• Synonyms: Lmet1; MMET-1
• Summary: The protein encoded by this gene is a member of a family of cytotoxic lymphocyte serine proteases called granzymes, which are expressed by cytotoxic T lymphocytes and natural killer cells. This protein belongs to a subfamily of granzymes that cleave after methionine residues. Natural killer cell development, homeostasis and cytotoxicity are normal in mice deficient for this gene, but they demonstrate increased susceptibility to murine cytomegalovirus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]