Mouse Sh2b3 activation kit by CRISPRa

CAT#: GA202480

Sh2b3 CRISPRa kit - CRISPR gene activation of mouse SH2B adaptor protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Sh2b3
• Locus ID: 16923
• Kit Components:

  GA202480G1, Sh2b3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202480G2, Sh2b3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202480G3, Sh2b3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001306126, NM_001306127, NM_001306128, NM_008507
• Synonyms: AI429800; Lnk
• Summary: This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]