Mouse Lta4h activation kit by CRISPRa

CAT#: GA202505

Lta4h CRISPRa kit - CRISPR gene activation of mouse leukotriene A4 hydrolase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Lta4h
• Locus ID: 16993
• Kit Components:

  GA202505G1, Lta4h gRNA vector 1 in pCas-Guide-CRISPRa

  GA202505G2, Lta4h gRNA vector 2 in pCas-Guide-CRISPRa

  GA202505G3, Lta4h gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001313897, NM_008517
• Summary: The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]