Mouse M6pr activation kit by CRISPRa

CAT#: GA202536

M6pr CRISPRa kit - CRISPR gene activation of mouse mannose-6-phosphate receptor, cation dependent

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: M6pr
• Locus ID: 17113
• Kit Components:

  GA202536G1, M6pr gRNA vector 1 in pCas-Guide-CRISPRa

  GA202536G2, M6pr gRNA vector 2 in pCas-Guide-CRISPRa

  GA202536G3, M6pr gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010749
• Synonyms: CD-MPR; Mpr46
• Summary: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. [UniProtKB/Swiss-Prot Function]