Mouse Mag activation kit by CRISPRa

CAT#: GA202554

Mag CRISPRa kit - CRISPR gene activation of mouse myelin-associated glycoprotein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mag
• Locus ID: 17136
• Kit Components:

  GA202554G1, Mag gRNA vector 1 in pCas-Guide-CRISPRa

  GA202554G2, Mag gRNA vector 2 in pCas-Guide-CRISPRa

  GA202554G3, Mag gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001346084, NM_001346085, NM_001346086, NM_001346087, NM_001346088, NM_001346089, NM_010758, NM_001369262
• Synonyms: Gma; siglec-4a
• Summary: This gene encodes a type I membrane protein and member of the immunoglobulin-like superfamily. It is expressed in myelinating glial cells, including oligodendrocytes of the central nervous system and Schwann cells of the peripheral nervous system. Mice lacking the encoded protein express abundant myelin, but suffer long-term axon degeneration, altered distribution of channels and adhesion molecules at nodes of Ranvier, and altered axon cytoskeletal structure. While not required for myelination, the encoded protein enhances axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]