Mouse Mdm4 activation kit by CRISPRa

CAT#: GA202622

Mdm4 CRISPRa kit - CRISPR gene activation of mouse transformed mouse 3T3 cell double minute 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mdm4
• Locus ID: 17248
• Kit Components:

  GA202622G1, Mdm4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202622G2, Mdm4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202622G3, Mdm4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001302801, NM_001302802, NM_001302803, NM_001302804, NM_008575, NR_126506
• Synonyms: 4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; Mdmx
• Summary: This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]