Mouse Mdm4 activation kit by CRISPRa

CAT#: GA202622

Mdm4 CRISPRa kit - CRISPR gene activation of mouse transformed mouse 3T3 cell double minute 4


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USD 1,290.00

2 Weeks*

Size
    • 1 kit

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Specifications

Product Data
Format 3gRNAs, 1 scramble ctrl and 1 enhancer vector
Symbol Mdm4
Locus ID 17248
Kit Components

GA202622G1, Mdm4 gRNA vector 1 in pCas-Guide-CRISPRa

GA202622G2, Mdm4 gRNA vector 2 in pCas-Guide-CRISPRa

GA202622G3, Mdm4 gRNA vector 3 in pCas-Guide-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100058

Disclaimer The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001302801, NM_001302802, NM_001302803, NM_001302804, NM_008575, NR_126506
Synonyms 4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; Mdmx
Summary This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.