Mouse Abcc1 activation kit by CRISPRa

CAT#: GA202623

Abcc1 CRISPRa kit - CRISPR gene activation of mouse ATP-binding cassette, sub-family C (CFTR/MRP), member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Abcc1
• Locus ID: 17250
• Kit Components:

  GA202623G1, Abcc1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202623G2, Abcc1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202623G3, Abcc1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008576
• Synonyms: Abcc1a; Abcc1b; Mdrap; MRP; Mrp1
• Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]