Mouse Mknk2 activation kit by CRISPRa

CAT#: GA202665

Mknk2 CRISPRa kit - CRISPR gene activation of mouse MAP kinase-interacting serine/threonine kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mknk2
• Locus ID: 17347
• Kit Components:

  GA202665G1, Mknk2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202665G2, Mknk2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202665G3, Mknk2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021462
• Synonyms: 2010016G11Rik; Gprk7; Mnk2
• Summary: The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]