Mouse Mmp11 activation kit by CRISPRa

CAT#: GA202676

Mmp11 CRISPRa kit - CRISPR gene activation of mouse matrix metallopeptidase 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mmp11
• Locus ID: 17385
• Kit Components:

  GA202676G1, Mmp11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202676G2, Mmp11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202676G3, Mmp11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001306184, NM_008606
• Synonyms: MMP-11; SL-3; ST3; Stmy3
• Summary: This gene encodes a member of the matrix metalloproteinase family of endopeptidases that are involved in remodeling extracellular matrix during, for example, embryonic development and tumor progression. The encoded protein undergoes post-translational proteolytic processing by furin endopeptidase to form an active enzyme. Subcutaneous introduction of cells expressing the encoded protein into nude mice results in increased tumor incidence. Mice lacking the encoded protein exhibit a decreased incidence of chemically-induced tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]