Mouse Mmp3 activation kit by CRISPRa

CAT#: GA202683

Mmp3 CRISPRa kit - CRISPR gene activation of mouse matrix metallopeptidase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mmp3
• Locus ID: 17392
• Kit Components:

  GA202683G1, Mmp3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202683G2, Mmp3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202683G3, Mmp3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010809
• Synonyms: EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1; STR-1; Str1
• Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein is activated by the removal of an N-temrinal activation peptide to generate a zinc-dependent endopeptidase with a broad range of substrates such as proteoglycans, laminin, fibronectin, elastin, and collagens. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]