Mouse Mmp9 activation kit by CRISPRa

CAT#: GA202686

Mmp9 CRISPRa kit - CRISPR gene activation of mouse matrix metallopeptidase 9

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mmp9
• Locus ID: 17395
• Kit Components:

  GA202686G1, Mmp9 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202686G2, Mmp9 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202686G3, Mmp9 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013599
• Synonyms: AW743869; B/MMP9; Clg4b; Gel B; MMP-9; pro-MMP-9
• Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]