Mouse Mapt activation kit by CRISPRa

CAT#: GA202743

Mapt CRISPRa kit - CRISPR gene activation of mouse microtubule-associated protein tau

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mapt
• Locus ID: 17762
• Kit Components:

  GA202743G1, Mapt gRNA vector 1 in pCas-Guide-CRISPRa

  GA202743G2, Mapt gRNA vector 2 in pCas-Guide-CRISPRa

  GA202743G3, Mapt gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001038609, NM_001285454, NM_001285455, NM_001285456, NM_010838
• Synonyms: AI413597; AW045860; Mtapt; Tau
• Summary: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. [UniProtKB/Swiss-Prot Function]