Mouse Mx2 activation kit by CRISPRa

CAT#: GA202774

Mx2 CRISPRa kit - CRISPR gene activation of mouse MX dynamin-like GTPase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mx2
• Locus ID: 17858
• Kit Components:

  GA202774G1, Mx2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202774G2, Mx2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202774G3, Mx2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013606, NR_003508
• Synonyms: AI528743; Mx-2
• Summary: This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to vesicular stomatitis virus, a member of the rhabdovirus family, but not to influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a frameshift that inactivates this gene product. [provided by RefSeq, Jul 2008]