Mouse Ndn activation kit by CRISPRa

CAT#: GA202846

Ndn CRISPRa kit - CRISPR gene activation of mouse necdin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ndn
• Locus ID: 17984
• Kit Components:

  GA202846G1, Ndn gRNA vector 1 in pCas-Guide-CRISPRa

  GA202846G2, Ndn gRNA vector 2 in pCas-Guide-CRISPRa

  GA202846G3, Ndn gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010882
• Synonyms: AI528698; Peg6
• Summary: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences. [UniProtKB/Swiss-Prot Function]