Mouse Ndufa2 activation kit by CRISPRa

CAT#: GA202849

Ndufa2 CRISPRa kit - CRISPR gene activation of mouse NADH:ubiquinone oxidoreductase subunit A2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ndufa2
• Locus ID: 17991
• Kit Components:

  GA202849G1, Ndufa2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202849G2, Ndufa2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202849G3, Ndufa2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010885
• Synonyms: AV000592; B8; C1-B8; CI-B8
• Summary: This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. The human ortholog of this gene has been characterized, and its structure and redox potential is reported to be similar to that of thioredoxins. It may be involved in regulating complex I activity or assembly via assistance in redox processes. In humans, mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. A pseudogene of this gene is located on chromosome 5. [provided by RefSeq, May 2013]