Mouse Nppb activation kit by CRISPRa

CAT#: GA202950

Nppb CRISPRa kit - CRISPR gene activation of mouse natriuretic peptide type B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Nppb
• Locus ID: 18158
• Kit Components:

  GA202950G1, Nppb gRNA vector 1 in pCas-Guide-CRISPRa

  GA202950G2, Nppb gRNA vector 2 in pCas-Guide-CRISPRa

  GA202950G3, Nppb gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001287348, NM_008726
• Synonyms: AA408272; BNF; BNP
• Summary: This gene encodes a secreted protein that belongs to the family of natriuretic peptides. Its precursor protein is processed to generate the active mature peptide. The mature peptide is a cardiac hormone that plays a role in ventricular remodeling as well as blood pressure regulation. Mice lacking this gene exhibit cardiac fibrosis. In humans this gene is associated with congestive heart failure, low bone-mineral density and postmenopausal osteoporosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]