Mouse Nrxn1 activation kit by CRISPRa

CAT#: GA202971

Nrxn1 CRISPRa kit - CRISPR gene activation of mouse neurexin I

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Nrxn1
• Locus ID: 18189
• Kit Components:

  GA202971G1, Nrxn1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202971G2, Nrxn1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202971G3, Nrxn1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001346957, NM_001346958, NM_001346959, NM_001346960, NM_001346961, NM_001346962, NM_001347419, NM_020252, NM_177284
• Synonyms: 1700062G21Rik; 9330127H16Rik; A230068P09Rik; mKIAA0578
• Summary: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]