Mouse Musk activation kit by CRISPRa

CAT#: GA202979

Musk CRISPRa kit - CRISPR gene activation of mouse muscle, skeletal, receptor tyrosine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Musk
• Locus ID: 18198
• Kit Components:

  GA202979G1, Musk gRNA vector 1 in pCas-Guide-CRISPRa

  GA202979G2, Musk gRNA vector 2 in pCas-Guide-CRISPRa

  GA202979G3, Musk gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001037127, NM_001037128, NM_001037129, NM_001037130, NM_001165996, NM_010944
• Synonyms: Mdk4; Mlk; Nsk1; Nsk2; Nsk3
• Summary: This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]