Mouse Ntf3 activation kit by CRISPRa

CAT#: GA202982

Ntf3 CRISPRa kit - CRISPR gene activation of mouse neurotrophin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ntf3
• Locus ID: 18205
• Kit Components:

  GA202982G1, Ntf3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202982G2, Ntf3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202982G3, Ntf3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164034, NM_001164035, NM_008742
• Synonyms: AI316846; AI835689; HDNF; NGF-2; Nt3; Ntf-3
• Summary: This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane receptor tyrosine kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]