Mouse Enpp2 activation kit by CRISPRa

CAT#: GA203164

Enpp2 CRISPRa kit - CRISPR gene activation of mouse ectonucleotide pyrophosphatase/phosphodiesterase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Enpp2
• Locus ID: 18606
• Kit Components:

  GA203164G1, Enpp2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA203164G2, Enpp2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA203164G3, Enpp2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136077, NM_001285994, NM_001285995, NM_015744
• Synonyms: ATX; E-NPP 2; lysoPLD; Npps2; PD-Ialpha; Pdnp2
• Summary: This gene encodes a member of the phosphodiesterase and nucleotide pyrophosphatase family of bifunctional enzymes that hydrolize phosphodiester bonds of various nucleotides. The encoded protein undergoes proteolytic processing to generate a mature protein with lysophospholipase D activity, catalyzing the cleavage of the choline group from lysophosphatidylcholine to produce lysophosphatidic acid. This gene is expressed in numerous tissues and participates in neural development, obesity, inflammation and oncogenesis. A complete lack of the encoded protein in mice results in aberrant vascular and neuronal development leading to embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]