Mouse Pla2g2a activation kit by CRISPRa

CAT#: GA203264

Pla2g2a CRISPRa kit - CRISPR gene activation of mouse phospholipase A2, group IIA (platelets, synovial fluid)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Pla2g2a
• Locus ID: 18780
• Kit Components:

  GA203264G1, Pla2g2a gRNA vector 1 in pCas-Guide-CRISPRa

  GA203264G2, Pla2g2a gRNA vector 2 in pCas-Guide-CRISPRa

  GA203264G3, Pla2g2a gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001082531, NR_002926, NM_011108
• Synonyms: EF; Mom1; Pla2; sPLA2; sPla2-IIA
• Summary: Proteins belonging to the phospholipase A2 (PLA2) family hydrolyze phospholipids into sn2 fatty acids and lysophospholipids. They function in a variety of cellular processes, including the digestion of phospholipids and the production of molecules that induce inflammatory responses. This gene encodes a member of the group II class of secretory PLA2s. The secreted enzyme binds to heparin on the cell surface. Mutations in this gene increase the occurrence of intestinal polyps caused by a dominant mutation in the adenomatosis polyposis coli gene. A frameshift inactivates this gene product in some mouse strains including the strain of the reference genome, C57BL/6J, whereas a functional protein is produced in other strains. [provided by RefSeq, Jul 2008]