Mouse Plat activation kit by CRISPRa

CAT#: GA203273

Plat CRISPRa kit - CRISPR gene activation of mouse plasminogen activator, tissue

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Plat
• Locus ID: 18791
• Kit Components:

  GA203273G1, Plat gRNA vector 1 in pCas-Guide-CRISPRa

  GA203273G2, Plat gRNA vector 2 in pCas-Guide-CRISPRa

  GA203273G3, Plat gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008872
• Synonyms: AU020998; AW212668; D8Ertd2e; tPA
• Summary: This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological processes such as synaptic plasticity, cell migration and tissue remodeling. Mice lacking the encoded protein display a reduction in long-term potentiation in hippocampus and conversely, transgenic mice overexpressing the encoded protein have increased and prolonged long-term potentiation. [provided by RefSeq, Jul 2015]