Mouse Ppargc1a activation kit by CRISPRa

CAT#: GA203342

Ppargc1a CRISPRa kit - CRISPR gene activation of mouse peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ppargc1a
• Locus ID: 19017
• Kit Components:

  GA203342G1, Ppargc1a gRNA vector 1 in pCas-Guide-CRISPRa

  GA203342G2, Ppargc1a gRNA vector 2 in pCas-Guide-CRISPRa

  GA203342G3, Ppargc1a gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008904, NR_027710, NR_132764
• Synonyms: A830037N07Rik; ENSMUSG00000079510; Gm11133; PGC-1; Pgc-1alpha; Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1
• Summary: This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]