Mouse Proc activation kit by CRISPRa

CAT#: GA203399

Proc CRISPRa kit - CRISPR gene activation of mouse protein C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Proc
• Locus ID: 19123
• Kit Components:

  GA203399G1, Proc gRNA vector 1 in pCas-Guide-CRISPRa

  GA203399G2, Proc gRNA vector 2 in pCas-Guide-CRISPRa

  GA203399G3, Proc gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042767, NM_001042768, NM_001313938, NM_008934, NR_045173
• Synonyms: PC
• Summary: This gene encodes the vitamin K-dependent protein C, which plays a vital role in the anticoagulation pathway. The encoded protein undergoes proteolytic processing including activation by thrombin-thrombomodulin complex to form the anticoagulant serine protease that degrades activated coagulation factors. A complete lack of the encoded protein in mice results in severe perinatal consumptive coagulopathy in the brain and liver, resulting in death within 24 hours after birth. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]