Mouse Lgmn activation kit by CRISPRa

CAT#: GA203411

Lgmn CRISPRa kit - CRISPR gene activation of mouse legumain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Lgmn
• Locus ID: 19141
• Kit Components:

  GA203411G1, Lgmn gRNA vector 1 in pCas-Guide-CRISPRa

  GA203411G2, Lgmn gRNA vector 2 in pCas-Guide-CRISPRa

  GA203411G3, Lgmn gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_011175
• Synonyms: AEP; AI746452; AU022324; Prsc1
• Summary: This gene encodes a member of the cysteine peptidase family C13 that plays an important role in the endosome/lysosomal degradation system. The encoded inactive preproprotein undergoes autocatalytic removal of the C-terminal inhibitory propeptide to generate the active endopeptidase that cleaves protein substrates on the C-terminal side of asparagine residues. Mice lacking the encoded protein exhibit defects in the lysosomal processing of proteins resulting in their accumulation in the lysosomes, and develop symptoms resembling hemophagocytic lymphohistiocytosis. [provided by RefSeq, Aug 2016]