Mouse Psen2 activation kit by CRISPRa

CAT#: GA203422

Psen2 CRISPRa kit - CRISPR gene activation of mouse presenilin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Psen2
• Locus ID: 19165
• Kit Components:

  GA203422G1, Psen2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA203422G2, Psen2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA203422G3, Psen2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001128605, NM_011183
• Synonyms: Ad4h; ALG-3; Alg3; PS-2; PS2; Psnl2; STM2
• Summary: This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011]