Mouse Pthlh activation kit by CRISPRa

CAT#: GA203462

Pthlh CRISPRa kit - CRISPR gene activation of mouse parathyroid hormone-like peptide

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Pthlh
• Locus ID: 19227
• Kit Components:

  GA203462G1, Pthlh gRNA vector 1 in pCas-Guide-CRISPRa

  GA203462G2, Pthlh gRNA vector 2 in pCas-Guide-CRISPRa

  GA203462G3, Pthlh gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008970
• Synonyms: PLP; PTH-like; Pthrp
• Summary: This gene encodes a member of the parathyroid family of hormones that possesses distinct paracrine and intracrine signaling roles such as regulation of circulating calcium, transplacental calcium transport, osteoclast inhibition, renal bicarbonate excretion and regulation of apoptosis. The encoded protein undergoes proteolytic processing to generate multiple active peptides with distinct signaling functions. The homozygous deletion of this gene leads to death shortly after birth with a chondrodystrophic phenotype characterized by premature chondrocyte differentiation and accelerated bone formation. [provided by RefSeq, Jul 2015]