Mouse Ptpre activation kit by CRISPRa

CAT#: GA203489

Ptpre CRISPRa kit - CRISPR gene activation of mouse protein tyrosine phosphatase, receptor type, E

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ptpre
• Locus ID: 19267
• Kit Components:

  GA203489G1, Ptpre gRNA vector 1 in pCas-Guide-CRISPRa

  GA203489G2, Ptpre gRNA vector 2 in pCas-Guide-CRISPRa

  GA203489G3, Ptpre gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001316678, NM_001316679, NM_001316680, NM_001316681, NM_011212
• Synonyms: PTPe; PTPepsilon; RPTPepsilon
• Summary: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). [UniProtKB/Swiss-Prot Function]