Mouse Rnf4 activation kit by CRISPRa

CAT#: GA203654

Rnf4 CRISPRa kit - CRISPR gene activation of mouse ring finger protein 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Rnf4
• Locus ID: 19822
• Kit Components:

  GA203654G1, Rnf4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA203654G2, Rnf4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA203654G3, Rnf4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001304269, NM_001304270, NM_011278
• Synonyms: AU018689; Gtrgeo8; SNURF
• Summary: This gene encodes a small nuclear RING finger protein that mediates ubiquitylation of polysumoylated proteins. Deficiency of the encoded protein in mice leads to embryonic lethality and global DNA hypermethylation. A similar protein in humans is required for arsenic-induced degradation of promyelocytic leukemia protein in acute promyelocytic leukemia. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 10. [provided by RefSeq, Jan 2015]