Mouse Snrpn activation kit by CRISPRa

CAT#: GA204013

Snrpn CRISPRa kit - CRISPR gene activation of mouse small nuclear ribonucleoprotein N

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Snrpn
• Locus ID: 20646
• Kit Components:

  GA204013G1, Snrpn gRNA vector 1 in pCas-Guide-CRISPRa

  GA204013G2, Snrpn gRNA vector 2 in pCas-Guide-CRISPRa

  GA204013G3, Snrpn gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001082961, NM_001082962, NM_013670, NM_001349690, NM_001349691, NM_001349692, NM_001349693, NM_001349694, NM_001349695
• Synonyms: 2410045I01Rik; HCERN3; Peg4; Pwcr1; SMN
• Summary: This locus represents a paternally-expressed imprinted gene that encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing. Genomic and genetic changes in this region result in growth defects and lethality; the corresponding region in human is the critical region for Prader-Willi Syndrome. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants may be bicistronic and also encode the SNRPN upstream reading frame protein (Snurf) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (Snhg14) may originate from the promoters at this locus and incorporate exons shared with this gene. [provided by RefSeq, Mar 2017]