Mouse Sox2 activation kit by CRISPRa

CAT#: GA204034

Sox2 CRISPRa kit - CRISPR gene activation of mouse SRY (sex determining region Y)-box 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Sox2
• Locus ID: 20674
• Kit Components:

  GA204034G1, Sox2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204034G2, Sox2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204034G3, Sox2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_011443
• Synonyms: lcc; Sox-2; ysb
• Summary: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in a similar gene in human have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (Sox2ot). [provided by RefSeq, Sep 2015]