Mouse Sparc activation kit by CRISPRa

CAT#: GA204048

Sparc CRISPRa kit - CRISPR gene activation of mouse secreted acidic cysteine rich glycoprotein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Sparc
• Locus ID: 20692
• Kit Components:

  GA204048G1, Sparc gRNA vector 1 in pCas-Guide-CRISPRa

  GA204048G2, Sparc gRNA vector 2 in pCas-Guide-CRISPRa

  GA204048G3, Sparc gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001290817, NM_009242
• Synonyms: BM-40; ON
• Summary: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. [UniProtKB/Swiss-Prot Function]