Mouse Sptlc2 activation kit by CRISPRa

CAT#: GA204099

Sptlc2 CRISPRa kit - CRISPR gene activation of mouse serine palmitoyltransferase, long chain base subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Sptlc2
• Locus ID: 20773
• Kit Components:

  GA204099G1, Sptlc2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204099G2, Sptlc2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204099G3, Sptlc2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_011479
• Synonyms: LCB2; LCB2a; Spt2
• Summary: This gene encodes a long chain base subunit of serine palmitoyltransferase. The enzyme, serine palmitoyltransferase, consists of two different subunits, and is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. A mutant allele of this gene in mice is used as a model for the human disease 'Susceptibilty to Psoriasis 1'. Mutations in the human gene are associated with hereditary sensory neuropathy type I. [provided by RefSeq, Sep 2015]