Mouse Tap1 activation kit by CRISPRa

CAT#: GA204208

Tap1 CRISPRa kit - CRISPR gene activation of mouse transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Tap1
• Locus ID: 21354
• Kit Components:

  GA204208G1, Tap1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204208G2, Tap1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204208G3, Tap1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001161730, NM_013683
• Synonyms: ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1; PSF1; RING4; TAP; Tap-1; Y3
• Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]