Mouse Trim24 activation kit by CRISPRa

CAT#: GA204349

Trim24 CRISPRa kit - CRISPR gene activation of mouse tripartite motif-containing 24

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Trim24
• Locus ID: 21848
• Kit Components:

  GA204349G1, Trim24 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204349G2, Trim24 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204349G3, Trim24 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001272064, NM_001272076, NM_145076
• Synonyms: A130082H20Rik; AI447469; D430004I05Rik; TIF1; TIF1-alpha; Tif1a; TIF1alpha
• Summary: The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]