Mouse Uba3 activation kit by CRISPRa

CAT#: GA204518

Uba3 CRISPRa kit - CRISPR gene activation of mouse ubiquitin-like modifier activating enzyme 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Uba3
• Locus ID: 22200
• Kit Components:

  GA204518G1, Uba3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204518G2, Uba3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204518G3, Uba3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001111106, NM_001301857, NM_001301858, NM_001301859, NM_011666
• Synonyms: A830034N06Rik; AI256736; AI848246; AW546539; Ube1c
• Summary: The protein encoded by this gene is the catalytic subunit of the enzyme that activates NEDD8, a ubiquitin-like molecule that binds to its target proteins through an enzymatic reaction analagous to ubiquitylation. Embryonic mice deficient for this protein die prior to implantation and display apoptosis of the inner cell mass. Trophoblastic cells cannot enter S phase, demonstrating that this gene is required for cell cycle progression during embryogenesis. Two pseudogenes have been found for this gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]