Mouse Uba1 activation kit by CRISPRa

CAT#: GA204519

Uba1 CRISPRa kit - CRISPR gene activation of mouse ubiquitin-like modifier activating enzyme 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Uba1
• Locus ID: 22201
• Kit Components:

  GA204519G1, Uba1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204519G2, Uba1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204519G3, Uba1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136085, NM_001276316, NM_001276317, NM_009457
• Synonyms: A1S9; Sbx; Ube-1; Ube1x
• Summary: This gene encodes a member of the ubiquitin-activating E1 family. The encoded protein initiates the ubiquitin activation and transfer cascade, catalyzing the first step in ubiquitin conjugation to mark cellular proteins for proteasome degradation. Ubiquitin activating enzymes use ATP to form a thioester between a conserved catalytic cysteine of the enzyme and the C-terminal carboxylate of ubiquitin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]