Mouse Eif4h activation kit by CRISPRa
CAT#: GA204622
Eif4h CRISPRa kit - CRISPR gene activation of mouse eukaryotic translation initiation factor 4H
Find the corresponding CRISPRi Inhibitor Kit
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 3gRNAs, 1 scramble ctrl and 1 enhancer vector |
Symbol | Eif4h |
Locus ID | 22384 |
Kit Components | GA204622G1, Eif4h gRNA vector 1 in pCas-Guide-CRISPRa GA204622G2, Eif4h gRNA vector 2 in pCas-Guide-CRISPRa GA204622G3, Eif4h gRNA vector 3 in pCas-Guide-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100058 |
Disclaimer | The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001312867, NM_033561 |
Synonyms | AU018978; D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H; Wbscr1; Wscr1 |
Summary | This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN505133 | Eif4h - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
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