Mouse Xpc activation kit by CRISPRa

CAT#: GA204658

Xpc CRISPRa kit - CRISPR gene activation of mouse xeroderma pigmentosum, complementation group C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Xpc
• Locus ID: 22591
• Kit Components:

  GA204658G1, Xpc gRNA vector 1 in pCas-Guide-CRISPRa

  GA204658G2, Xpc gRNA vector 2 in pCas-Guide-CRISPRa

  GA204658G3, Xpc gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009531
• Summary: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by Rad23b and Rad23a. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. [UniProtKB/Swiss-Prot Function]