Mouse Zap70 activation kit by CRISPRa

CAT#: GA204677

Zap70 CRISPRa kit - CRISPR gene activation of mouse zeta-chain (TCR) associated protein kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Zap70
• Locus ID: 22637
• Kit Components:

  GA204677G1, Zap70 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204677G2, Zap70 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204677G3, Zap70 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001289612, NM_001289765, NM_001289766, NM_009539
• Synonyms: mrtle; mur; Srk; ZAP-70
• Summary: This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]