Mouse Papss2 activation kit by CRISPRa

CAT#: GA204846

Papss2 CRISPRa kit - CRISPR gene activation of mouse 3'-phosphoadenosine 5'-phosphosulfate synthase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Papss2
• Locus ID: 23972
• Kit Components:

  GA204846G1, Papss2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204846G2, Papss2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204846G3, Papss2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001201470, NM_011864, NM_001360403
• Synonyms: 1810018P12Rik; AI159688; Atpsk2; AtpsU2; bm; Sk2
• Summary: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth. [UniProtKB/Swiss-Prot Function]