Mouse Rnf13 activation kit by CRISPRa

CAT#: GA204865

Rnf13 CRISPRa kit - CRISPR gene activation of mouse ring finger protein 13

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Rnf13
• Locus ID: 24017
• Kit Components:

  GA204865G1, Rnf13 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204865G2, Rnf13 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204865G3, Rnf13 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001113413, NM_001304454, NM_001304456, NM_011883, NR_130743, NM_001357080
• Synonyms: 2010001H16Rik; Rzf
• Summary: This gene encodes a member of the PA-TM-RING family of proteins that contain a protease associated (PA) domain and a RING finger domain separated by a transmembrane (TM) domain. The encoded protein is an E3 ubiquitin ligase localized to the endosomal-lysosomal vesicles and inner nuclear membrane. Mice lacking the encoded protein have impaired learning abilities associated with a decreased synaptic vesicle density and dysregulated SNARE complex assembly. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on the X chromosome. [provided by RefSeq, Jan 2015]