Mouse Mga activation kit by CRISPRa

CAT#: GA205224

Mga CRISPRa kit - CRISPR gene activation of mouse MAX gene associated

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mga
• Locus ID: 29808
• Kit Components:

  GA205224G1, Mga gRNA vector 1 in pCas-Guide-CRISPRa

  GA205224G2, Mga gRNA vector 2 in pCas-Guide-CRISPRa

  GA205224G3, Mga gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164274, NM_013720
• Synonyms: AV312082; C80739; C130042M01Rik; D030062C11Rik; Mad5
• Summary: Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor. [UniProtKB/Swiss-Prot Function]